11/25/2023 0 Comments Chromium side effects children![]() Trial RegistrationĬlinical Trial Registration Number: NCT01225198 This suggests that a vitamin/mineral supplement is a reasonable adjunct therapy to consider for most children and adults with autism. The supplement group had significantly greater improvements than did the placebo group on the PGI-R Average Change. Oral vitamin/mineral supplementation is beneficial in improving the nutritional and metabolic status of children with autism, including improvements in methylation, glutathione, oxidative stress, sulfation, ATP, NADH, and NADPH. R 2 = 0.61, p < 0.0005) with the initial levels of biotin and vitamin K being the most significant (p < 0.05) both biotin and vitamin K are made by beneficial intestinal flora. Regression analysis revealed that the degree of improvement on the Average Change of the PGI-R was strongly associated with several biomarkers (adj. For the other three assessment tools the difference between treatment group and placebo group was not statistically significant. The supplement group had significantly greater improvements than the placebo group on the Parental Global Impressions-Revised (PGI-R, Average Change, p = 0.008), and on the subscores for Hyperactivity (p = 0.003), Tantrumming (p = 0.009), Overall (p = 0.02), and Receptive Language (p = 0.03). Most of these metabolic biomarkers improved to normal or near-normal levels. Levels of many vitamins, minerals, and biomarkers improved/increased showing good compliance and absorption. The vitamin/mineral supplement was generally well-tolerated, and individually titrated to optimum benefit. ![]() For a subset of the participants (53 children ages 5-16) pre and post measurements of nutritional and metabolic status were also conducted. None of the participants had taken a vitamin/mineral supplement in the two months prior to the start of the study. The study involved 141 children and adults with autism, and pre and post symptoms of autism were assessed. This study is a randomized, double-blind, placebo-controlled three month vitamin/mineral treatment study. ![]() Vitamin/mineral supplements are among the most commonly used treatments for autism, but the research on their use for treating autism has been limited. ![]()
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